Published: 5 September 2024

Publications

MARC’s remarks: June 2024 meeting

Published: 5 September 2024
Prescriber Update 45(3): 54
September 2024

The Medicines Adverse Reaction Committee (MARC) convened for their 198th meeting on 13 June 2024.

The Committee discussed the risk of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) with systemic antibiotics and systemic antifungals. They noted that SDRIFE is associated with many medicines, particularly beta lactam antibiotics and antifungals, and SDRIFE is listed as an adverse reaction in the amoxicillin + clavulanic acid data sheets. The Committee commented that SDRIFE is usually self-limiting and the sequelae are rare, and acknowledged the recent Prescriber Update article about SDRIFE (December 2023). They agreed that the skin reaction warnings in the medicine data sheets are adequate, and no further actions are needed.

The Committee noted a Medsafe review of Bexsero vaccine adverse reaction reports and agreed with Medsafe’s conclusion that these reports do not raise any new safety concerns. The Committee also acknowledged the Prescriber Update article: Summary of Bexsero adverse events following immunisation (June 2024), which was based on this review.

See the Medsafe website for the MARC meeting minutes and the reports presented to the MARC.