Published: 7 December 2023

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Quiz answers

Published: 7 December 2023
Prescriber Update 44(4): 86
December 2023

1. Antipsychotics can inhibit the action of which neurotransmitters, resulting in prolonged gastrointestinal time and contributing to constipation?
   1. acetylcholine, dopamine or glutamate
   2. gamma-aminobutyric acid (GABA), norepinephrine or serotonin
   3. acetylcholine, histamine or serotonin
   4. glutamate, histamine or norepinephrine
   c. Antipsychotics can inhibit the action of acetylcholine, histamine or serotonin, resulting in prolonged gastrointestinal transit time, which contributes to constipation. (June 2023)
2. Unless covered by an exemption or blanket approval, which classes of controlled drugs require approval from the Minister of Health to supply, prescribe and administer?
   Unless covered by an exemption or blanket approval, individual ministerial approval is required to supply, prescribe and administer Class A, B1, B2 and C1 controlled drugs. (September 2023)
3. Metoclopramide use in children and young adults is limited to certain conditions and as second-line therapy due to the risk of what type of side effects?
   Due to the risk of dystonic side effects, metoclopramide use in children and young adults (aged 1 to 19 years, inclusive) is limited to certain conditions and as second-line therapy. (March 2023)
4. [Name of medicine] may be fatal if ingested by pets.
   Efudix cream may be fatal if ingested by pets. (December 2023)
5. List the four risk factors for antidepressant withdrawal symptoms.
   Antidepressant withdrawal symptoms can happen any time an antidepressant is reduced or stopped, but is more likely when:
   • antidepressants are stopped abruptly
   • antidepressants are tapered too quickly
   • someone has been taking a high dose of antidepressants
   • someone has been on antidepressants for a long time. (September 2023)
6. Baboon syndrome is the original name for which drug-induced rash?
   Baboon syndrome is the original name for symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), a drug-induced rash involving the skin folds. (December 2023)
7. Which of the following is the most well-known DPYD variant associated with dihydropyrimidine dehydrogenase deficiency?
   1. DPYD*13
   2. c.2846A>T
   3. HapB3
   4. DPYD*2A
   d. DPYD*2A is the most well-known DPYD variant associated with DPD deficiency. Variants DPYD*13, c.2846A>T and HapB3 have also been associated with altered DPD activity. (March 2023)
8. True or false: Patients with evidence of corneal epithelial breakdown should have their ocular NSAID dose increased.
   False. Patients with evidence of corneal epithelial breakdown should immediately discontinue ocular NSAID treatment. (June 2023)
9. To reduce the risk of ______, consider reducing the patient’s insulin dose when co-prescribing it with dulaglutide.
   To reduce the risk of hypoglycaemia, consider reducing the patient’s insulin dose when co-prescribing it with dulaglutide. (December 2023)
10. If a renally-impaired patient is being treated with cefepime and develops a new onset neurological condition, what might they be experiencing?
    Renal impairment and a new onset neurological condition associated with cefepime may be indicative of cephalosporin-induced neurotoxicity. (March 2023)