Published: 1 December 2022

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Test your knowledge: the Prescriber Update quiz 2022

Prescriber Update 43(4): 55
December 2022

Have you been reading Prescriber Update in 2022? Have you kept up to date with emerging safety signals? Test your knowledge with the end-of-year Prescriber Update quiz.

1. Non-steroidal autoinflammatory drugs (NSAIDs) are contraindicated during which trimester of pregnancy?
2. Trimethoprim or _____ can interact with methotrexate to cause bone marrow suppression.
3. List 3 factors that increase the risk of diabetic ketoacidosis in patients taking a sodium-glucose co-transporter 2 (SGLT-2) inhibitor.
4. Systemic ciprofloxacin may [increase/decrease] the serum concentration of levothyroxine.
5. Consider drug–drug interactions with Paxlovid (nirmatrelvir + ritonavir) due to its inhibitory effects on:
   1. CYP3A
   2. CYP2D6
   3. CYP2C9
   4. CYP1A2
6. Patients taking bimatoprost who have mild enophthalmos, orbital fat atrophy and/or inferior scleral show may be experiencing which condition?
7. In patients taking combined oral contraceptives (COCs), when is the risk of venous thromboembolism (VTE) the highest?
8. List 3 opioid medicines that are high-risk for inducing serotonin syndrome when used with serotonergic medicines.
9. Which of the following are suggested mechanisms whereby vitamin E may cause bleeding:
   1. Scavenging of free radicals
   2. Inhibition of platelet aggregation
   3. Tocopheryl quinone has anticoagulant activity
   4. Alpha-tocopherol can interfere with vitamin K metabolism
10. True or False: St John’s Wort can reduce the clinical effects of warfarin.

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